Ammonium iodide → HCID 58423951, compound

Participants

Reaction Steps

A solution of 6-bromo-1′-methyl-2′-(methylthio)-2-(thiophen-2-yl)spiro[chroman-4,4′-imidazol]-5′(1′H)-one (20 mg, 0.047 mmol), NH4I (13.7 mg, 0.094 mmol) in a solution of NH3/EtOH (2 mL, 2 N) was heated at 110° C. in a tube in a microwave reactor for 2-2.5 h. After cooling, the mixture was concentrated in vacuum to give the residue, which was purified by preparative TLC to afford 2′-amino-6-bromo-1′-methyl-2-(thiophen-2-yl)spiro[chroman-4,4′-imidazol]-5′(1′H)-one (5 mg, 20%). 1H-NMR (CDCl3): 2.52 (m, 2H), 3.14 (s, 3H), 6.12 (d, 1H), 6.94 (d, 1H), 7.02 (t, 1H), 7.14 (d, 1H), 7.43 (t, 3H).

Provenance & Evidence