反应详情

温度

110 °C

To a solution of 6-bromo-2-phenylspiro[chroman-4,4′-imidazolidine]-2′,5′-dione (440 mg, 1.18 mmol) in 1,4-dioxane (3.6 mL) in a 10 mL CEM microwave test tube was added Lawesson's reagent (477 mg, 1.18 mmol). The resulting mixture was heated in a CEM microwave reactor at 110° C. for 40 min and then cooled to room temperature. The solvent was removed in vacuo, and the residue was purified by flash chromatography to give 6-bromo-2-phenyl-2′-thioxospiro[chroman-4,4′-imidazolidin]-5′-one (238 mg, 52%). MS m/z 389 (M+H+).

1. temperaturecooled to room temperature
2. customThe solvent was removed in vacuo
3. customthe residue was purified by flash chromatography