Lawesson's reagent → HCID 58424626, compound

Participants

Reaction Steps

A suspension of 6-bromo-2-(3-fluorophenyl)spiro[chroman-4,4′-imidazolidine]-2′,5′-dione (300 mg, 0.77 mmol) and Lawesson's reagent (312 mg, 0.77 mmol) in dry 1,4-dioxane (10 mL) was refluxed for 24 h. The mixture was concentrated in vacuo and the residue was purified by preparative TLC to give 6-bromo-2-(3-fluorophenyl)-2′-thioxospiro[chroman-4,4′-imidazolidine]-5′-one (35 mg, 17%).

Provenance & Evidence