反应详情

A suspension of 6-bromo-2-phenylspiro[chroman-4,4′-imidazolidine]-2′,5′-dione (186 mg, 0.5 mmol) and Lawesson's Reagent (202 mg, 0.5 mmol) in dry 1,4-dioxane (8 mL) was refluxed for 24 h. The mixture was concentrated in vacuo and the residue was purified by preparative TLC to give 6-bromo-2-phenyl-2′-thioxospiro[chroman-4,4′-imidazolidin]-5′-one (115 mg, 62%). 1H-NMR (CDCl3): 2.35 (t, 1H), 2.49 (dd, 1H), 5.83 (d, 1H), 6.90 (d, 1H), 7.36-7.45 (m, 7H).

1. temperaturewas refluxed for 24 h
2. concentrationThe mixture was concentrated in vacuo
3. customthe residue was purified by preparative TLC