Acetate → Tert-butyl 3-[[2-[7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl]quinolin-8-yl]amino]pyrrolidine-1-carboxylate

HRID 140864Notes

Reaction equation

HRID 140864 reaction equation
[Br:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[cH:7][cH:8][c:9](-[c:12]3[cH:13][n:14][c:15]4[n:16]3[cH:17][cH:18][c:19]([O:21][CH2:22][CH2:23][O:24][CH3:25])[cH:20]4)[n:10][c:11]12.[C:39](=[O:40])([O-:41])[O-:42].[CH3:48][c:49]1[cH:50][cH:51][cH:52][cH:53][cH:54]1.[Cl:45][CH2:46][Cl:47].[Cs+:43].[Cs+:44].[NH2:26][CH:27]1[CH2:28][N:29]([C:32](=[O:33])[O:34][C:35]([CH3:36])([CH3:37])[CH3:38])[CH2:30][CH2:31]1.[O-:56][C:57]([CH3:58])=[O:59].[O-:60][C:61]([CH3:62])=[O:63].[Pd+2:55]>>[c:2]1([NH:26][CH:27]2[CH2:28][N:29]([C:32](=[O:33])[O:34][C:35]([CH3:36])([CH3:37])[CH3:38])[CH2:30][CH2:31]2)[cH:3][cH:4][cH:5][c:6]2[cH:7][cH:8][c:9](-[c:12]3[cH:13][n:14][c:15]4[n:16]3[cH:17][cH:18][c:19]([O:21][CH2:22][CH2:23][O:24][CH3:25])[cH:20]4)[n:10][c:11]12

Participants

9

Reactant 8

HCID 175Acetate2×HCID 1140TolueneHCID 6344DichloromethaneHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 27563701-Boc-3-aminopyrrolidineHCID 667815638-Bromo-2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinoline

Product 1

HCID 66782045Tert-butyl 3-[[2-[7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl]quinolin-8-yl]amino]pyrrolidine-1-carboxylate

Sources & evidence

ORD record
ord-4647437d508b4b0e971e771e8bdb7bc5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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