Lawesson's reagent → HCID 58423941, compound

Participants

Reaction Steps

A suspension of 6-methyl-2-phenylspiro[chroman-4,4′-imidazolidine]-2′,5′-dione (200 mg, 0.65 mmol) and Lawesson's Reagent (263 mg, 0.65 mmol) in anhydrous 1,4-dioxane (8 mL) was refluxed for 24 h. The mixture was concentrated in vacuo and the residue was purified by preparative TLC to give 6-methyl-2-phenyl-2′-thioxospiro[chroman-4,4′-imidazolidin]-5′-one (35 mg, 17%). 1H-NMR (CDCl3): 2.28 (s, 3H), 2.47 (d, 1H), 2.51 (d, 1H), 5.30 (s, 1H), 6.92 (s, 1H), 6.70 (d, 2H), 7.10 (m, 1H), 7.41 (m, 1H), 8.18 (s, 1H).

Provenance & Evidence