Ammonium iodide → HCID 58423991, compound

Participants

Reaction Steps

A solution of 1′-methyl-2′-(methylthio)-2-phenylspiro[chroman-4,4′-imidazol]-5′(1′H)-one (50 mg, 0.148 mmol) and NH4I (42.9 mg, 0.296 mmol) in NH3/EtOH (4 mL, 1.5 N) is heated at 110° C. in a tube under microwave reactor for 2-2.5 h. After cooling, the mixture is concentrated in vacuo to give a residue, which is purified by preparative TLC to afford 2′-amino-1′-methyl-2-phenylspiro[chroman-4,4′-imidazol]-5′(1′H)-one (5 mg, 10%).

Provenance & Evidence