Hydrochloric Acid → HCID 70652268, compound

Participants

Reaction Steps

A solution of 48 (2.50 g, 6.10 mmol) in dichloromethane (13.6 mL) was treated at 0° C. with 4 mol/L HCl in 1,4-dioxane (9.2 mL, 36.6 mmol) followed by methanol (2.0 mL). The flask was sealed with a rubber septa and the mixture was then stirred at room temperature for 4 hrs. The reaction mixture was diluted with ether and the precipitate was washed several times with ether and dried under reduced pressure to afford 1.8 g (86%) of 49 which was confirmed by LC/MS and was used directly for the next step.

Provenance & Evidence