tert-Butanol → HCID 86684756, compound

Participants

Reaction Steps

AD-mix-beta (27.8 g) was added portion wise to a solution of 51 (2.7 g, 16.2 mmol) in t-butanol (83 mL) and H2O (83 mL) at 5° C. The mixture was stirred at room temperature for 16 hrs and then cooled to 5° C. and treated with excess sodium sulfite for 20 min. It was diluted with water and extracted with ethyl acetate. The organic layer was separated, washed with brine, dried over sodium sulfate, concentrated and chromatographed on silica gel eluted with 67% ethyl acetate in hexanes and ethyl acetate to afford 3.2 g (98%) of 52 as an oil which was confirmed by LC/MS and was used directly for the next step.

Provenance & Evidence