HCID 68291601, compound → HCID 68291783, compound

Participants

Reaction Steps

A mixture of benzyl (1R,3R)-3-hydroxy-2,2,3-trimethylcyclopentylcarbamate (900 mg, 3.24 mmol, from Step 1) and 10% palladium on carbon (173 mg) in methanol (15 mL) was stirred under hydrogen at 20 psi for 2 h. The mixture was filtered to remove the catalyst. The filtrate was concentrated to give (1R,3R)-3-amino-1,2,2-trimethylcyclopentanol (450 mg, 97% yield). 1H NMR (400 MHz, methanol-d4) δ ppm 3.11-3.52 (1 H, m), 1.98-2.43 (1 H, m), 1.75-1.93 (1 H, m), 1.56-1.71 (1 H, m), 1.27-1.48 (1 H, m), 1.16 (3 H, s), 0.93 (3 H, s), 0.72 (3 H, s).

Provenance & Evidence