HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Fluoro-2-methylcyclopentanamine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | Tert-butyl 2-fluoro-2-methylcyclopentylcarbamate | HCID 68291793 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Fluoro-2-methylcyclopentanamine hydrochloride | HCID 68292055 | 96% |
Reaction Steps
A 4 M dioxane solution of hydrogen chloride (6.30 mL, 25.2 mmol) was added to a stirred solution of tert-butyl 2-fluoro-2-methylcyclopentylcarbamate (1.0954 g, 5.04 mmol, from Step 4) in dichloromethane (4 mL) at room temperature. After 1.5 h at room temperature, the solvent was evaporated to give 2-fluoro-2-methylcyclopentanamine hydrochloride (740 mg, 96% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08921368B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-b058887c95dd4abf9aa778b1169a105c |
| Source note | uspto-grants-2014_12 |