反应详情

Following conditions described in Step 1 of Intermediate 22, 6-bromo-4-(3-hydroxy-2,2-dimethylcyclopentylamino)pyrrolo[1,2-b]pyridazine-3-carboxamide (395 mg, 1.076 mmol, from Step 1) was converted to 6-bromo-4-(2,2-dimethyl-3-oxocyclopentylamino)pyrrolo[1,2-b]pyridazine-3-carboxamide (320 mg, 80% yield). 1H NMR (400 MHz, methanol-d4) δ ppm 8.19 (1 H, s), 7.69 (1 H, d, J=1.76 Hz), 7.16 (1 H, d, J=1.76 Hz), 2.36-2.73 (3 H, m), 1.89-2.06 (1 H, m), 1.15 (6 H, s); MS (ES+) m/z: 365.2, 367.1 (M+H).