Hydrochloric Acid → HCID 86707704, compound

Participants

Reaction Steps

A mixture of 3-(benzylamino)-2-fluoro-1,2-dimethylcyclopentanol (415 mg, 1.749 mmol, from Step 3), 10% palladium on carbon (93 mg) in methanol (10 mL) and 4 N aqueous hydrochloric acid (0.481 mL, 1.924 mmol) was stirred under hydrogen at 34 psi for 15 h. After removal of catalyst by filtration, the filtrate was concentrated to give (1R,2R,3R)-3-amino-2-fluoro-1,2-dimethylcyclopentanol (racemic mixture) as a hydrochloride salt. 1H NMR (400 MHz, methanol-d4) δ ppm 3.51-3.85 (1 H, m), 2.21-2.55 (1 H, m), 1.95-2.15 (1 H, m), 1.59-1.83 (2 H, m), 1.13-1.57 (6H, m).

Provenance & Evidence