HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Pyrrolidone → 4-(((1R)-2,2-dimethylcyclopentyl)amino)-6-(2-oxo-1-pyrrolidinyl)pyrrolo[1,2-b]pyridazine-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Pyrrolidone | HCID 12025 | — |
| Reactant | (R)-6-bromo-4-(2,2-dimethylcyclopentylamino)pyrrolo[1,2-b]pyridazine-3-carboxamide | HCID 68291536 | — |
| Product | 4-(((1R)-2,2-dimethylcyclopentyl)amino)-6-(2-oxo-1-pyrrolidinyl)pyrrolo[1,2-b]pyridazine-3-carboxamide | HCID 68358802 | — |
Reaction Steps
4-(((1R)-2,2-dimethylcyclopentyl)amino)-6-(2-oxo-1-pyrrolidinyl) pyrrolo[1,2-b]pyridazine-3-carboxamide was prepared from Intermediate 50 and pyrrolidin-2-one using a similar procedure as described for the preparation of Example 312 LCMS: 356.18 (M+H)+; HPLC (condition L): retention time=7.44 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08921368B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-a8319700303e42779b69160e3848ddc4 |
| Source note | uspto-grants-2014_12 |