Acetic Acid → HCID 86707708, compound

Participants

Reaction Steps

A mixture of 4-((1R,3S)-3-amino-2,2,3-trimethylcyclopentylamino)-6-(4-(aminomethyl)phenyl)pyrrolo[1,2-b]pyridazine-3-carboxamide (Example 234, 8 mg, 0.020 mmol), acetic acid (1.8 mg, 0.03 mmol), BOP (1.3 mg, 0.022 mmol) and DIPEA (6.35 mg, 0.05 mmol) in DMF (0.5 mL) was stirred at rt for 2 h. The reaction was purified by preparative HPLC to afford the title compound (4 mg, 38% yield). LCMS: 491.32 (M+H); HPLC (condition B): retention time=3.51 min; 1H NMR (CDCl3, 400 MHz) δ 7.95 (s, 1H), 7.78 (s, 1H), 7.51 (m, 2H), 7.29 (m, 2H), 7.00 (m, 1H), 4.46 (M, 1H), 4.37 (s, 2H), 2.34 (m, 2H), 1.97 (m, 6H), 1.72 (m, 1H), 3.28 (s, 3H), 1.06 (s, 6H).

Provenance & Evidence