Potassium Hydroxide → HCID 68358882, compound

Participants

Reaction Conditions

Reaction Steps

A 4.5 M aqueous potassium hydroxide (192 μl, 0.866 mmol) solution was added dropwise to a solution of (1S,3R)-methyl 3-(3-carbamoyl-6-phenylpyrrolo[1,2-b]pyridazin-4-ylamino)-1,2,2-trimethyl-cyclopentanecarboxylate (182 mg, 0.433 mmol) in ethanol (2885 μl). The reaction was heated at 75° C. for 24 hrs. The reaction was cooled to room temperature and concentrated under reduced pressure, yielding an oil. The oil was diluted with ethyl acetate and washed with water. The aqueous layer was acidified with 1.0 N HCl and was extracted with ethyl acetate (3×). The organic extracts were combined, dried with sodium sulfate, filtered and concentrated under reduced pressure, yielding (1S,3R)-3-(3-carbamoyl-6-phenylpyrrolo[1,2-b]pyridazin-4-ylamino)-1,2,2-trimethylcyclopentanecarboxylic acid (152.8 mg, 0.376 mmol, 87% yield) as a yellow solid. LC/MS found [M+H]+=407.0.

Provenance & Evidence