Potassium Hydroxide → HCID 68358955, compound

Participants

Reaction Conditions

Reaction Steps

A 4.5 M aqueous solution of potassium hydroxide (210 μl, 0.945 mmol) was added dropwise to a solution of (1S,3R)-methyl 3-(6-bromo-3-carbamoylpyrrolo[1,2-b]pyridazin-4-ylamino)-1,2,2-trimethylcyclopentanecarboxylate (200 mg, 0.472 mmol) in ethanol (3.2 ml). The reaction was heated at 75° C. for 24 hrs. The reaction was cooled to room temperature and concentrated under reduced pressure to yield an oil. The oil was diluted with ethyl acetate and washed with water. The aqueous layer was acidified with 1.0 N HCl and was extracted with ethyl acetate (3×). The organic extracts were combined, dried with sodium sulfate, filtered and concentrated under reduced pressure, yielding the title compound (182 mg, 0.422 mmol, 89% yield) as a pale yellow solid. LC/MS found [M+H]+=410.7.

Provenance & Evidence