Cyanuric chloride → HCID 68358959, compound

Participants

Reaction Steps

To a solution of (1R,3S)-methyl 3-carbamoyl-2,2,3-trimethylcyclopentane carboxylate (4.49 g, 21.05 mmol) in DMF (35 ml) at room temperature was added cyanuric chloride (2.329 g, 12.63 mmol). The reaction mixture was stirred for 14 hrs. The reaction solution was partitioned between water and ethyl acetate. The ethyl acetate extracts were combined, washed with brine, dried over sodium sulfate, filtered, and concentrated under reduced pressure, yielding (1R,3S)-methyl 3-cyano-2,2,3-trimethylcyclopentanecarboxylate (3.73 g, 19.10 mmol, 91% yield) as a white solid. ESI-MS m/z 218.2 ([M+H]+).

Provenance & Evidence