Trifluoroacetic acid → HCID 68358961, compound

Participants

Reaction Steps

To a solution of tert-butyl (((1S,3S)-3-((3-carbamoyl-6-phenylpyrrolo[1,2-b]pyridazin-4-yl)amino)-1,2,2-trimethylcyclopentyl)methyl)carbamate (236 mg, 0.480 mmol) in dichloromethane (3910 μl) at 0° C. was added trifluoroacetic acid (452 μl, 5.87 mmol. The reaction mixture was allowed to warm to room temperature and stirring was continued for 1 hr. The reaction mixture was concentrated under reduced pressure, yielding a yellow oil. The oil was diluted with ethyl acetate (50 ml) and washed successively with saturated sodium bicarbonate, water, and saturated sodium chloride. The ethyl acetate extract was dried with sodium sulfate, filtered, and concentrated under reduce pressure, yielding 4-(((1S,3S)-3-(aminomethyl)-2,2,3-trimethylcyclopentyl)amino)-6-phenylpyrrolo[1,2-b]pyridazine-3-carboxamide (182 mg, 0.465 mmol, 97% yield) as a tan solid. ESI-MS m/z 392.3 ([M+H]+).

Provenance & Evidence