Potassium hydroxy sulfite → HCID 68291798, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-(ethylthio)-6-(2-methyl-2H-tetrazol-5-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide (64 mg, 0.211 mmol) in acetone (1.0 mL) was added oxone (285 mg, 0.464 mmol) in water (1.0 mL). The reaction mixture was stirred at 23° C. for 1 hr. The reaction mixture was added 5 ml of water and stirred for 10 minutes. The solid was collected as the desired product (57.4 mg, 85% yield). 1H NMR (400 MHz, methanol-d4) δ 8.59 (d, J=1.8 Hz, 1H), 8.52 (s, 1H), 8.27 (d, J=1.5 Hz, 1H), 4.46 (s, 3H), 3.55-3.42 (m, 2H), 1.53 (s, 3H). MS (ES+) m/z: 320.10 (M+H); HPLC retention time: 2.007 min (analytical HPLC Method F).

Provenance & Evidence