1-[4-(5-Cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine dihydrochloride → 2-benzofurancarboxamide, 5-(4-(4-(5-cyano-1H-indol-3-yl)butyl)-1-piperazinyl)-, hydrochloride (1:1)
Reaction equation
[ClH:1].Cl.[C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH:9]=[C:8]2[CH2:14][CH2:15][CH2:16][CH2:17][N:18]1[CH2:23][CH2:22][N:21]([C:24]2[CH:25]=[CH:26][C:27]3[O:31][C:30]([C:32](=[O:34])[NH2:33])=[CH:29][C:28]=3[CH:35]=2)[CH2:20][CH2:19]1)#[N:4]>O>[ClH:1].[C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH:9]=[C:8]2[CH2:14][CH2:15][CH2:16][CH2:17][N:18]1[CH2:19][CH2:20][N:21]([C:24]2[CH:25]=[CH:26][C:27]3[O:31][C:30]([C:32](=[O:34])[NH2:33])=[CH:29][C:28]=3[CH:35]=2)[CH2:22][CH2:23]1)#[N:4]Participants
3
Procedure
10 g of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine dihydrochloride Form XIII are dispersed in 11 water. After stirring for 48 hours the crystals are recovered by filtration, and drying in vacuo to constant weight at room temperature leads to 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine hydrochloride hydrate of Form V.
Workup
- filtrationare recovered by filtration
- customdrying in vacuo to constant weight at room temperature
Sources & evidence
- ORD record
- ord-84314a96427742b38f46d7730ac58e9d
- Source dataset
- uspto-grants-2014_12
- Patent number
- US08921375B2
Reaction notes
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