Diisopropylethylamine → HCID 58896782, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 2-bromo-6-fluoropyridine (1.23 g, 7 mmol) and (S)-2-amino-N-(2,2,2-trifluoroethyl)propanamide hydrochloride (FF) (1.44 g, 7 mmol) in NMP (10 mL) was treated with DIPEA (2.4 mL, 14 mmol) and heated at 220° C. for 40 min in the microwave. After complete reaction, the mixture was diluted with ethylacetate (100 mL) then washed with water (5×25 mL), brine (1×25 mL) then dried over Na2SO4. The solvent was removed and the residue purified with silica-gel chromatography using hexane:ethyl acetate (4:1) to afford 1.5 g (66% yield) of a white solid, GG. LC-MS: 2.8 min, 327.8 ES+; 1H NMR (500 MHz, dmso-d6) d 8.56 (m, 1H), 7.29 (t, 1H), 7.13 (d, 1H), 6.68 (d, 1H), 6.55 (d, 1H), 4.36 (m, 1H), 3.90 (m, 2H), 1.30 (d, 3H).

Provenance & Evidence