Sodium Bicarbonate → HCID 86714621, compound

Participants

Reaction Steps

2-Chloro-3,6-difluoro-4-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)-benzonitrile (0.853 mmol, 0.276 g) was stirred in ethanol. 10% HCl/EtOH solution (5 ml) was slowly added. The resulting mixture was stirred at RT overnight. The reaction mixture was neutralized with NaHCO3 and extracted twice with EtOAc. The combined organics were washed with water, dried, filtered and evaporated. 0.219 g of the title compound was obtained. 1H-NMR (400 MHz, DMSO-d6): δ 6.86 (bs, 1H), 7.88-8.10 (m, 2H), 13.57 (bs, 1H).

Provenance & Evidence