Stannane, tributyl(1-ethoxyethenyl)- → HCID 86714623, compound

HRID 1409304Notes

Reaction equation

HRID 1409304 reaction equation
Cl[C:2]1[O:3][CH:4]=[C:5]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[N:6]=1.C([Sn](CCCC)(CCCC)[C:17]([O:19][CH2:20][CH3:21])=[CH2:18])CCC>>[CH2:20]([O:19][C:17]([C:2]1[O:3][CH:4]=[C:5]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[N:6]=1)=[CH2:18])[CH3:21]

Participants

3

Reactant 2

HCID 619414Stannane, tributyl(1-ethoxyethenyl)-HCID 2763184Ethyl 2-chlorooxazole-4-carboxylate

Product 1

HCID 86714623HCID 86714623, compound

Procedure

Ethyl 2-(1-ethoxyvinyl)oxazole-4-carboxylate was prepared using the procedure described in Example 33(a), starting from ethyl 2-chlorooxazole-4-carboxylate (10.5 g, 59.8 mmol) and tributyl(1-ethoxyvinyl)stannane (24 ml, 65.8 mmol), The product was purified with flash-chromatography. Yield 10.3 g. 1H-NMR (400 MHz; CDCl3): δ ppm 1.23-1.46 (m, 6H), 3.94-3.99 (m, 2H), 4.36-4.42 (m, 2H), 4.8 (d, 1H), 5.33 (s, 1H), 8.19 (s, 1H).

Workup

  1. customThe product was purified with flash-chromatography

Sources & evidence

ORD record
ord-b378c6b3bbeb402aaacd275ff04939fa
Source dataset
uspto-grants-2014_12
Patent number
US08921378B2

Reaction notes

Loading…