(S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chloro-6-fluorobenzonitrile → HCID 136377296, compound

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Reaction Steps

The title compound was prepared using the procedure described in Example 3(h), starting from 1,6-dihydropyrrolo[2,3-c]pyrazole-5-carboxylic acid (0.280 mmol, 0.042 g) and (S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chloro-6-fluorobenzo-nitrile (0.215 mmol, 0.080 g). The crude product was purified by preparative HPLC. 0.0164 g of the title compound was obtained. 1H-NMR (400 MHz, MeOH-d4): δ 1.29 (d, 3H), 4.27-4.34 (m, 1H), 4.36-4.43 (m, 1H), 4.50-4.60 (m, 1H), 6.75-6.79 (m, 2H), 7.58 (s, 1H), 7.60-7.65 (m, 1H), 7.69 (d, 1H), 7.79-7.82 (m, 1H).

Provenance & Evidence