Sodium Hydroxide → HCID 70981082, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 6-(3,3-dimethylureido)imidazo[1,2-a]pyridine-2-carboxylate (0.239 mmol, 0.066 g) was dissolved in ethanol (5 ml). The solution was cooled to 0° C. and NaOH 2 M solution (0.478 mmol, 0.239 ml) was added. The resulting mixture was stirred at 0° C. Ethanol was evaporated and water was added. The pH of the water phase was adjusted to ˜4 with HCl. The mixture was extracted with EtOAc and the organic phase was dried, filtered and evaporated. The residue was triturated with MeOH/DCM 1/9. The filtered precipitate was dried under vacuum. 0.067 g of the title compound was obtained. LC-MS: [M−1]=247.24.

Provenance & Evidence