Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) → HCID 66576287, compound

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Reaction Steps

The title compound was prepared using the procedure described in Example 3(h) starting from 6-(methylsulfonamido)imidazo[1,2-a]pyridine-2-carboxylic acid (0.215 mmol, 0.055 g) and (S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chloro-6-fluorobenzo-nitrile (0.179 mmol, 0.050 g) using DCM (10 ml) as the solvent. HBTU (0.018 mmol, 6.80 mg) was used instead of HOBt. The mixture was diluted with DCM and washed with Na2CO3 solution and water. The organic phase was evaporated. The water phase and Na2CO3 phase were washed with EtOAc. The evaporated organic phases were combined and purified by preparative HPLC. 0.0174 g of the title compound was obtained. 1H-NMR (400 MHz, DMSO-d6): δ 1.14 (d, 3H), 3.04 (s, 3H), 4.27-4.58 (m, 3H), 7.00 (d, 1H), 7.27 (dd, 1H), 7.57-7.62 (m, 1H), 7.87 (d, 1H), 7.91 (dd, 1H), 7.95-7.97 (m, 1H), 8.36 (d, 1H), 8.49-8.51 (m, 1H), 8.55 (d, 1H), 9.77 (s, 1H).

Provenance & Evidence