Sodium Hydroxide → HCID 63383100, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 5-(isoxazol-3-yl)-1,2,4-oxadiazole-3-carboxylate (1.893 mmol, 0.396 g) was dissolved in ethanol (5 ml) and cooled to 0° C. with an ice bath. NaOH 1 M solution (4 ml) was slowly added and the mixture was heated to 60° C. for 3 h. Ethanol was evaporated and the residue was diluted with MTBE. The mixture was cooled to 0° C. and acidified by adding 2 M HCl. The mixture was stirred at RT overnight. Water was added and the phases were separated and the water phase was evaporated. 0.533 g of the title compound was obtained. 1H-NMR (400 MHz, D2O): δ 6.68 (d, 1H), 8.65 (d, 1H).

Provenance & Evidence