Sodium Hydroxide → HCID 70982355, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 3-(1-trityl-1H-imidazol-4-yl)-1H-pyrazole-5-carboxylate (4.01 mmol, 1.8 g) was dissolved in ethanol (20 ml) and cooled to 0° C. NaOH 2 M solution (8.03 mmol, 4.01 ml) was added and the mixture was stirred at RT for an hour. The mixture was heated to 60° C. and stirred for 10 h. Ethanol was evaporated and the residue was diluted with water. The pH was adjusted to 4 with 1 M HCl solution which precipitated the product. The precipitate was removed by filtration and washed with water. The solid was dried under vacuum. 1.5 g of the title compound was obtained. 1H-NMR (400 MHz, DMSO-d6): δ 6.75 (bs, 1H), 7.08-7.17 (m, 6H), 7.18-7.34 (m, 5H), 7.36-7.49 (m, 8H). LC-MS: [M−1]=419.1.

Provenance & Evidence