Sodium borohydride → HCID 86714652, compound

Participants

Reaction Steps

(S)-2-Acetyl-N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-4-carboxamide (290 mg, 0.53 mmol) was dissolved in MeOH (20 ml). NaBH4 (30 mg, 0.79 mmol) was added to the solution in portions at 0° C. and the mixture was stirred at RT for 3 h. The reaction mixture was concentrated and dluted with water. The mixture was extracted with DCM and the organic layer was concentrated. The product was purified by column chromatography. Yield 245 mg. 1H-NMR (400 MHz; DMSO-d6): δ −0.05 (s, 9H), 0.81-0.86 (m, 2H), 1.07-1.1 (m, 3H), 1.49 (d, 3H), 3.47-3.51 (m, 2H), 4.29-4.43 (m, 3H), 4.88-4.91 (m, 1H), 5.4-5.45 (m, 3H), 7.03 (d, 1H), 7.68 (d, 1H), 7.86-8.00 (m, 4H).

Provenance & Evidence