Dimethylformamide → HCID 66576762, compound

Participants

Reaction Steps

The title compound was prepared using the procedure described in Example 3(h) starting from 5-(2-hydroxypropan-2-yl)-1H-pyrazole-3-carboxylic acid (0.646 mmol, 110 mg) and (S)-4-(1-(2-amino-propyl)-1H-pyrazol-3-yl)-2-chlorobenzonitrile (0.539 mmol, 140 mg) using DMF (2 ml) as the solvent. Water was added and the mixture was extracted three times with DCM. The combined organics were washed twice with water. The separated organic phase was evaporated and the residue was purified by flash chromatography and preparative HPLC, respectively. 44.6 mg of the title compound was obtained. 1H-NMR (400 MHz; DMSO-d6): δ 1.11 (d, 3H), 1.45 (s, 6H), 4.22-4.52 (m, 3H), 5.31 (s, 1H), 6.37 (s, 1H), 6.94 (d, 1H), 7.81 (d, 1H), 7.88-8.03 (m, 2H), 8.09 (s, 1H), 8.16 (d, 1H), 12.96 (s, 1H).

Provenance & Evidence