(S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chlorobenzonitrile → HCID 66576844, compound

Participants

Reaction Steps

The title compound was prepared using the procedure described in Example 3(h) starting from 1-(2-methylprop-1-en-1-yl)-1H-pyrazole-3-carboxylic acid (1.151 mmol, 191 mg) and (S)-4-(1-(2-amino-propyl)-1H-pyrazol-3-yl)-2-chlorobenzonitrile (0.959 mmol, 250 mg) using DCM (5 ml) as the solvent. The mixture was diluted with DCM and washed with 1 M Na2CO3. The organic phase was dried, filtered and evaporated. The crude product was purified flash chromatography. 297 mg of the title compound was obtained. 1H-NMR (400 MHz, DMSO-d6): δ 1.12 (d, 3H), 1.80 (d, 3H), 1.85 (d, 3H), 4.25-4.52 (m, 3H), 6.66 (d, 1H), 6.77-6.81 (m, 1H), 6.95 (d, 1H), 7.83 (t, 2H), 7.94-7.97 (m, 2H), 8.06-8.10 (m, 1H), 8.18 (d, 1H).

Provenance & Evidence