Methanol → HCID 178418785, compound

Participants

Reaction Conditions

Reaction Steps

1H-Imidazole-4-carboxylic acid (5 g, 44.6 mmol) was dissolved in MeOH (100 ml). Into the solution, H2SO4 (10 ml) was added at 0° C. The resulting mixture was stirred at 80° C. for overnight. The solvent was concentrated under reduced pressure. The pH was adjusted to 9 with aqueous NaHCO3 solution and extracted with EtOAc. The organic layer was concentrated to give the product. Yield 5.2 g. 1H-NMR (400 MHz; DMSO-d6): δ 3.74 (s, 3H), 7.79 (bs, 2H), 12.75 (bs, 1H). LC-MS: [M+1]=127.23.

Provenance & Evidence