Potassium Carbonate → HCID 70981469, compound

Participants

Reaction Conditions

Reaction Steps

Into a flask containing a solution of methyl 2-isopropyl-1H-imidazole-4-carboxylate (2.7 g, 16.1 mmol) in DMF (20 ml), K2CO3 (5.5 g, 40.2 mmol) and SEM-Cl (3.5 g, 21.0 mmol) were added. The resulting mixture was heated at 80° C. for 18 h. The reaction mixture was diluted with H2O and extracted with EtOAc. The product was purified with flash chromatography. Yield 830 mg. 1H-NMR (400 MHz; CDCl3): δ 0.04 (s, 9H), 0.85-0.89 (m, 2H), 1.28 (d, 6H), 3.15-3.20 (m, 1H), 3.57 (t, 2H), 3.83 (s, 3H), 5.74 (s, 2H), 7.69 (s, 1H).

Provenance & Evidence