(S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chlorobenzonitrile → HCID 66576923, compound

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Reaction Steps

The title compound was prepared using the procedure described in Example 52(g) starting from (S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chlorobenzo-nitrile (664 mg, 2.55 mmol) and methyl 2-butyl-1-methyl-1H-imidazole-4-carboxylate (500 mg, 2.55 mmol). The product was purified with flash chromatography. Yield 291 mg. 1H-NMR (400 MHz; DMSO-d6): δ 0.88 (t, 3H), 1.09 (t, 3H), 1.28-1.36 (m, 2H), 1.54-1.61 (m, 2H), 2.62 (t, 2H), 3.57 (s, 3H), 4.26-4.39 (m, 3H), 6.95 (bs, 1H), 7.47 (s, 1H), 7.82 (d, 1H), 7.90 (d, 1H), 7.96 (s, 2H), 8.09 (s, 1H).

Provenance & Evidence