HCID 70981716, compound → HCID 70981750, compound

HRID 1409439Notes

Reaction equation

HRID 1409439 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([C:7]([O:9]CC2C=CC=CC=2)=[O:8])[N:4]=[C:3]1[C:17]1[CH:18]=[N:19][N:20]([CH3:22])[CH:21]=1>CCO.[Pd]>[CH3:1][N:2]1[CH:6]=[C:5]([C:7]([OH:9])=[O:8])[N:4]=[C:3]1[C:17]1[CH:18]=[N:19][N:20]([CH3:22])[CH:21]=1

Participants

4

Reactant 1

HCID 70981716HCID 70981716, compound

Product 1

HCID 70981750HCID 70981750, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Into a flask containing a solution of benzyl 1-methyl-2-(1-methyl-1H-pyrazol-4-yl)-1H-imidazole-4-carboxylate (1 g, 3.4 mmol) in EtOH (25 ml), 10% Pd/C (100 mg) was added at RT. The resulting mixture was stirred at RT under H2 atmosphere for 3 h. The reaction mixture was filtered through a celite bed and the filtrate was concentrated. The residue was triturated twice from diethyl ether. Yield 500 mg. LC-MS: [M+1]=207.04.

Workup

  1. additionwas added at RT
  2. filtrationThe reaction mixture was filtered through a celite bed
  3. concentrationthe filtrate was concentrated
  4. customThe residue was triturated twice from diethyl ether

Sources & evidence

ORD record
ord-9e9e02bf0d6a4d9889cb70bc7b1d8dbc
Source dataset
uspto-grants-2014_12
Patent number
US08921378B2

Reaction notes

Loading…