(S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chlorobenzonitrile → HCID 66575737, compound

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Reaction Steps

The title compound was prepared using the procedure described in Example 32(e) starting from 2-cyclopropyl-1-methyl-1H-imidazole-4-carboxylic acid (0.160 g, 0.96 mmol) and (S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chloro benzonitrile (0.251 g, 0.96 mmol). The product was purified with flash chromatography. Yield 166 mg. 1H-NMR (400 MHz; DMSO-d6): δ 0.80-0.92 (m, 4H), 1.07 (d, 3H), 1.94-1.98 (m, 1H), 3.65 (s, 3H), 4.26-4.38 (m, 3H), 6.95 (s, 1H), 7.47 (s, 1H), 7.75 (d, 1H), 7.81 (s, 1H); 7.96 (s, 2H), 8.08 (s, 1H). LC-MS: [M+1]=409.28.

Provenance & Evidence