N-Boc-(R)-1-amino-2-propanol → (S)-4-(1-(1-aminopropan-2-yl)-1H-pyrazol-3-yl)-2-chloro-6-fluorobenzonitrile

Participants

Reaction Steps

The title compound was prepared using the procedure described in Example 3(g) starting from 2-chloro-6-fluoro-4-(1H-pyrazol-3-yl)benzonitrile (13.5 mmol, 3 g) and (R)-tert-butyl (2-hydroxypropyl)carbamate (27 mmol, 4.72 g). Yield 1.3 g. 1H-NMR (400 MHz; CDCl3): δ 1.47 (d, 3H), 3.02-3.19 (m, 2H), 4.30-4.38 (m, 1H), 6.60 (d, 1H), 7.52-7.59 (m, 2H), 7.75 (s, 1H). LC-MS: [M+1]=279.17.

Provenance & Evidence