N-Boc-(S)-1-amino-2-propanol → (R)-4-(1-(1-aminopropan-2-yl)-1H-pyrazol-3-yl)-2-chloro-6-fluorobenzonitrile

Participants

Reaction Steps

The title compound was prepared using the procedure described in Example 3(g) starting from 2-chloro-6-fluoro-4-(1H-pyrazol-3-yl)benzonitrile (14.9 mmol, 3.3 g) and (S)-tert-butyl (2-hydroxypropyl)carbamate (29.8 mmol, 5.23 g). Yield 2.2 g. 1H-NMR (400 MHz; CDCl3): δ 1.53 (d, 3H), 3.44-3.61 (m, 2H), 4.48-4.54 (m, 1H), 6.59 (d, 1H), 7.48 (d, 1H), 7.55 (d, 1H), 7.75 (s, 1H). LC-MS: [M+1]=279.12.

Provenance & Evidence