HRID1409449

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C[C@H](CN)n1ccc(-c2cc(F)c(C#N)c(Cl)c2)n1

HCID70981642

未命名化合物

结构：CC(C)(O)c1nc(C(=O)O)cn1COCC[Si](C)(C)C

HCID70982153

未命名化合物

PRODUCTS

生成物

结构：C[C@H](CNC(=O)c1cn(COCC[Si](C)(C)C)c(C(C)(C)O)n1)n1ccc(-c2cc(F)c(C#N)c(Cl)c2)n1

HCID86714663

未命名化合物

PROCEDURE

实验过程

The title compound was prepared using the procedure described in Example 32(e) starting from 2-(2-hydroxypropan-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-4-carboxylic acid (1.43 mmol, 430 mg) and (R)-4-(1-(1-aminopropan-2-yl)-1H-pyrazol-3-yl)-2-chloro-6-fluorobenzonitrile (1.43 mmol, 400 mg). The product was purified by flash-chromatography. Yield 410 mg. LC-MS: [M+1]=561.21.

WORKUP

后处理

customThe product was purified by flash-chromatography

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f644663c783c4e4da62e69d5f21a4b9e
来源数据集: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08921378B2
来源说明: uspto-grants-2014_12

反应 SMILES

[OH:1][C:2]([C:5]1[N:6]([CH2:13][O:14][CH2:15][CH2:16][Si:17]([CH3:20])([CH3:19])[CH3:18])[CH:7]=[C:8]([C:10]([OH:12])=O)[N:9]=1)([CH3:4])[CH3:3].[NH2:21][CH2:22][C@H:23]([N:25]1[CH:29]=[CH:28][C:27]([C:30]2[CH:37]=[C:36]([F:38])[C:33]([C:34]#[N:35])=[C:32]([Cl:39])[CH:31]=2)=[N:26]1)[CH3:24]>>[Cl:39][C:32]1[CH:31]=[C:30]([C:27]2[CH:28]=[CH:29][N:25]([C@H:23]([CH3:24])[CH2:22][NH:21][C:10]([C:8]3[N:9]=[C:5]([C:2]([OH:1])([CH3:3])[CH3:4])[N:6]([CH2:13][O:14][CH2:15][CH2:16][Si:17]([CH3:20])([CH3:19])[CH3:18])[CH:7]=3)=[O:12])[N:26]=2)[CH:37]=[C:36]([F:38])[C:33]=1[C:34]#[N:35]