Sodium Hydroxide → HCID 86714666, compound

Participants

Reaction Steps

Ethyl 2-(2,2,2-trifluoroethyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-4-carboxylate (2.41 mmol, 850 mg) was dissolved in THF (30 ml) and H2O (20 ml). NaOH (4.82 mmol, 200 mg) was added and the mixture was stirred at RT for 48 h. The reaction mixture was concentrated and acidified to pH 2 using 1 N HCl. The mixture was extracted with DCM and the organic layer was concentrated. Yield 310 mg. LC-MS: [M+1]=325.01.

Provenance & Evidence