(S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chloro-6-fluorobenzonitrile → HCID 86714668, compound

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Reaction Steps

The title compound was prepared using the procedure described in Example 32(e) starting from 2-(trifluoromethyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-4-carboxylic acid (0.97 mmol, 300 mg) and (S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chloro-6-fluorobenzonitrile (0.97 mmol, 269 mg). The product was purified by flash-chromatography. Yield 230 mg. 1H-NMR (400 MHz; DMSO-d6): δ −0.13 (s, 9H), 0.65-0.77 (m, 2H), 1.17 (d, 3H), 3.36-3.43 (m, 2H), 4.21-4.42 (m, 3H), 5.75 (q, 2H), 7.01 (s, 1H), 7.64 (s, 1H), 7.83-7.88 (m, 2H), 7.95 (s, 1H), 8.65 (d, 1H). LC-MS: [M+1]=571.01.

Provenance & Evidence