Hydroxyamine hydrochloride → HCID 86714669, compound

Participants

Reaction Conditions

Reaction Steps

Into a flask containing 2-((tert-butyldiphenylsilyl)oxy)propanenitrile (14.6 mmol, 4.5 g) in MeOH (50 ml), NH2OH.HCl (29.1 mmol, 2 g) and NaHCO3 (43.7 mmol, 3.6 g) were added. The resulting mixture was stirred at 70° C. for overnight. The mixture was quenched with H2O and extracted with EtOAc. The organic layer was washed with H2O, dried, filtered and evaporated. Yield 4.02 g. 1H-NMR (400 MHz; DMSO-d6): δ 1.01 (s, 9H), 1.20 (d, 3H), 4.12 (q, 1H), 7.38-7.46 (m, 6H), 7.60-7.64 (m, 4H). LC-MS: [M+1]=343.12.

Provenance & Evidence