Triacetoxyperiodinane → HCID 86714671, compound

Participants

Reaction Steps

Into a flask containing ethyl 3-(1-hydroxyethyl)-1,2,4-oxadiazole-5-carboxylate (53.7 mmol, 10 g) in DCM (100 ml), Dess-Martin periodinane (80 mmol, 34.2 g) was added at 0° C. in portions and the resulting mixture was stirred at RT for 16 h. The reaction mixture was quenched with aqueous NaHCO3 solution and extracted with DCM. The organic layers were dried, filtered and evaporated. The product was purified by flash-chromatography. Yield 9.12 g. 1H-NMR (400 MHz; CDCl3): δ 1.47 (t, 3H), 2.76 (s, 3H), 4.58 (q, 2H).

Provenance & Evidence