Cyclopropylboronic acid → Benzyl 2-cyclopropyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-4-carboxylate

Participants

Reaction Steps

The title compound was prepared using the procedure described in Example 59(a) starting from benzyl 2-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-4-carboxylate (7.31 mmol, 3 g) and cyclopropylboronic acid (14.63 mmol, 1.25 g). Yield 1.02 g. 1H-NMR (400 MHz; CDCl3): δ −0.02 (s, 9H), 0.91 (t, 2H), 0.99 (bs, 2H), 1.15 (bs, 2H), 1.87-1.94 (m, 1H), 3.52 (t, 2H), 5.32 (s, 2H), 5.34 (s, 2H), 7.29-7.43 (m, 5H), 7.59 (s, 1H). LC-MS: [M+1]=373.31.

Provenance & Evidence