(S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chloro-6-fluorobenzonitrile → HCID 86714673, compound

Participants

Reaction Steps

The title compound was prepared using the procedure described in Example 32(e) starting from 2-cyclopropyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-4-carboxylic acid (1.41 mmol, 400 mg) and (S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chloro-6-fluorobenzonitrile (1.41 mmol, 395 mg). The product was purified by flash-chromatography. Yield 249 mg. 1H-NMR (400 MHz; CDCl3): δ −0.01 (s, 9H), 0.93 (t, 2H), 0.99 (d, 4H), 1.23 (d, 3H), 1.88-1.95 (m, 1H), 3.52 (t, 2H), 4.29-4.40 (m, 2H), 4.47-4.54 (m, 1H), 5.33 (s, 2H), 6.59 (d, 1H), 7.35 (d, 1H), 7.49-7.51 (m, 2H), 7.58 (d, 1H), 7.72 (s, 1H).

Provenance & Evidence