Ethyl cyanoformate → 4-Benzyl 2-ethyl 1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2,4-dicarboxylate

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Reaction Steps

The title compound was prepared using the procedure described in Example 52(d) starting from benzyl 2-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-4-carboxylate (0.609 mmol, 250 mg) and ethyl cyanoformate (0.91 mmol, 90 mg). Yield 97 mg. 1H-NMR (400 MHz; CDCl3): δ −0.08 (s, 9H), 0.91 (t, 2H), 1.42 (t, 3H), 3.57 (t, 2H), 4.43 (q, 2H), 5.38 (s, 2H), 5.78 (s, 2H), 7.30-7.39 (m, 3H), 7.43-7.46 (m, 2H), 7.90 (s, 1H). LC-MS: [M+1]=405.13.

Provenance & Evidence