(S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chloro-6-fluorobenzonitrile → HCID 86714675, compound

Participants

Reaction Steps

The title compound was prepared using the procedure described in Example 32(e) starting from 2-(ethoxycarbonyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-4-carboxylic acid (3.18 mmol, 1 g) and (S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chloro-6-fluorobenzonitrile (3.18 mmol, 890 mg). The product was purified by flash-chromatography. Yield 1.6 g. 1H-NMR (400 MHz; DMSO-d6): δ −0.01 (s, 9H), 0.80 (t, 2H), 1.15 (d, 3H), 1.30 (t, 3H), 3.48 (t, 2H), 4.34-4.49 (m, 5H), 5.69 (s, 2H), 6.98 (d, 1H), 7.78-7.82 (m, 2H), 7.87 (s, 1H), 8.03 (s, 1H), 8.21 (d, 1H). LC-MS: [M+1]=575.11.

Provenance & Evidence