Dimethylamine → HCID 86714677, compound

Participants

Reaction Steps

The title compound was prepared using the procedure described in Example 32(e) starting from (S)-4-((1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)carbamoyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxylic acid (0.549 mmol, 300 mg) and N,N-dimethylamine (0.824 mmol, 37 mg). The product was purified by flash-chromatography. Yield 207 mg. 1H-NMR (400 MHz; CDCl3): δ −0.01 (s, 9H), 0.91 (t, 2H), 1.26 (d, 3H), 3.11 (s, 3H), 3.26 (s, 3H), 3.54 (t, 2H), 4.31-4.42 (m, 2H), 4.51-4.57 (m, 1H), 5.74 (s, 2H), 6.59 (d, 1H), 7.39 (d, 1H), 7.49 (d, 1H), 7.59 (d, 1H), 7.81 (s, 1H), 7.84 (s, 1H). LC-MS: [M+1]=574.32.

Provenance & Evidence