(S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chloro-6-fluorobenzonitrile → HCID 86714678, compound

Participants

Reaction Steps

The title compound was prepared using the procedure described in Example 32(e) starting from 2-(2-ethoxypropan-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-4-carboxylic acid (1.15 mmol, 380 g) and (S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chloro-6-fluorobenzonitrile (1.15 mmol, 320 mg). The product was purified by flash-chromatography. Yield 260 mg. 1H-NMR (400 MHz; DMSO-d6): δ −0.01 (s, 9H), 0.80-0.91 (m, 5H), 0.94 (t, 3H), 1.23 (s, 6H), 3.21 (q, 2H), 3.58 (t, 2H), 4.33-4.42 (m, 2H), 4.53-4.59 (m, 1H), 5.53 (s, 2H), 6.61 (d, 1H), 7.41 (d, 1H), 7.52 (d, 1H), 7.59 (d, 1H), 7.64 (s, 1H), 7.74 (s, 1H). LC-MS: [M+1]=589.23.

Provenance & Evidence